aff. a suffix occurring in nouns that denote actions, conditions, or states (hypnosis; osmosis), esp. disorders or abnormal states (neurofibromatosis; tuberculosis)
Compare -otic
Etymology: on the model of Gk borrowings ending in Gk -ōsis, derived orig. from verbs ending in the formative -o- (-ō- in n. derivatives), with the suffix -sis -sis

From formal English to slang. 2014.

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